La Boussole opened as a francophone community center in January 1992 as a result of a research project about francophones residing in the Downtown Eastside. The project highlighted the need for access to a system of support services to be delivered in French and geared for francophones. The federal government through the Department of Canadian Heritage provided funding to establish the first community center for homeless francophones in British Columbia.

Incorporated in 1996, La Boussole held its first Annual General Meeting in 1997.The provision of social and community services has expanded over the years to include: health projects, job search assistance services with funding contributed by the three levels of government (federal, provincial and municipal).

In 2012, La Boussole opened an office in Surrey to serve newcomers who chose to settle in this fast-growing city. Settlement, social, employment and community-based initiatives are available at this location. As their old premises suffered heavy water damages in 2014, La Boussole is in the process of re-opening a new facility in the same perimeter, at the intersection of Broadway and Fraser Street. The Centre will be housed in a building owned by the City of Vancouver and as in the past, La Boussole will continue to be the sole and main provider in The Lower Mainland of social, community, employment services and health projects for all francophones.